Anti-MDM2 antibody [2A10] ab16895 from Abcam

Product Specs
ItemAnti-MDM2 antibody [2A10]
CompanyAbcam
Price Pricing Info Supplier Page View Supplier Product Page
Catalog Numberab16895
Antibody TypePrimary
ClonalityMonoclonal
Clone2A10
HostMouse, Nude mouse
Quantity50 UG
ApplicationsFlow Cytometry, Immunocytochemistry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
IsotypeIgG2a
Conjugate/TagUnconjugated
Concentration0.1 mg/ml
Gene NameMDM2
ReactivityHuman
TargetMDM2

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) A CRISPR-Cas9 library screening identifies CARM1 as a critical inhibitor of ferroptosis in hepatocellular carcinoma cellsMolecular Therapy - Nucleic AcidsDecember 12, 2023Yiming Cheng, Xiaochen Wang, Shuyu Huang, Liang Zhang, Bei Lan, Xuanyuan Li, Hao Chen, Zhenfeng Liu, Yijie Su, Lishan Xi, et al.using the mycoplasma detection kit (D101, Vazamy, Nanjing, China). Anti-GPX4 (ab125066), anti-MDM2 (ab16895) and anti-H3 (asymmetric di methyl R26) (ab194679) were purchased from Abcam Inc. (Cambridge, MA). Anti-β-actin

(2) The Molecular Basis for Selectivity of the Cytotoxic Response of Lung Adenocarcinoma Cells to Cold Atmospheric PlasmaBiomoleculesNovember 20, 2023Mikhail Biryukov, Dmitriy Semenov, Nadezhda Kryachkova, Alina Polyakova, Ekaterina Patrakova, Olga Troitskaya, Elena Milakhina, Julia Poletaeva, Pavel Gugin, Elena Ryabchikova, et al.(ab125066); anti-GPX7 (ab96257); anti-ATF3 (ab233797), anti-GADD45B (ab205252), γH2AFX (ab26350) and MDM2 (ab16895) (Abcam, Cambridge, UK), anti-β-Tubulin (T8328, Sigma-Aldrich, St. Louis, MO, USA); and goat anti-rabbit

(3) Deltonin enhances gastric carcinoma cell apoptosis and chemosensitivity to cisplatin via inhibiting PI3K/AKT/mTOR and MAPK signalingWorld Journal of Gastrointestinal OncologyOctober 15, 2023Lin Yang, Ya-Nan Liu, Yi Gu, Qi Guo(ab32503), anti-Bid (ab32060), anti-Bak (ab32371), anti-Fas (ab133619), anti-Rad51 (ab133534), anti-MDM2 (ab16895), anti-PI3K (ab32089), anti-mTOR (ab134903), anti-p-mTOR (ab137133), anti-p-PI3K (ab182651), anti-AKT

(4) UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosisRedox biologyJune 1, 2023Gan Y, Deng J, Hao Q, Huang Y, Han T, Xu JG, Zhao M, Yao L, Xu Y, Xiong J, et al.Signalway Antibody), anti-p53 (Cat. No. sc-126, DO-1, Santa Cruz Biotechnology), anti-MDM2 (Cat. No. ab16895, 2A10, Abcam), anti-GAPDH (Cat. No. 60004-1-Ig, Proteintech), anti-RPL5 (Cat. No. ab86863, Abcam), anti-RPL11

(5) Anticancer effect of involucrasin A on colorectal cancer cells by modulating the Akt/MDM2/p53 pathwayOncology LettersApril 12, 2023Chengming Wei, Jingjing Du, Yunfu Shen, Zi Wang, Qianyu Lin, Junhe Chen, Fuming Zhang, Wanjun Lin, Zhibin Wang, Zhuya Yang, et al.Santa Cruz Biotechnology, Inc.); anti-p-MDM2 (cat. no. ab170880; rabbit monoclonal) and anti-MDM2 (cat. no. ab16895; mouse monoclonal) (both from Abcam). The anti-rabbit (cat. no. 211-035-109) and anti-mouse (cat. no.

(6) Quercetin Induces Apoptosis in HepG2 Cells via Directly Interacting with YY1 to Disrupt YY1-p53 InteractionMetabolitesFebruary 3, 2023Hui Guan, Wenyuan Zhang, Hui Liu, Yang Jiang, Feng Li, Maoyu Wu, Geoffrey I. N. Waterhouse, Dongxiao Sun-Waterhouse, Dapeng Li(ab109237, 1:5000, Abcam, Waltham, MA, USA), p53 (ab32389, 1:10000, Abcam, Cambridge, MA, USA), HDM2 (ab16895,1:500, Abcam, USA), Bcl-2 (ab196495, 1:500, Abcam, USA), Bax (ab182733, 1:2000, Abcam, Cambridge, MA,

(7) RPL15 promotes hepatocellular carcinoma progression via regulation of RPs-MDM2-p53 signaling pathwayCancer Cell InternationalDecember 1, 2022Rui Shi, Zirong Liup21 (1:3000; Abcam, ab188224, MA, USA), p53 (1:1000; Abcam, ab32049, MA, USA), MDM2 (1:1000; Abcam, ab16895, MA, USA), RPL5 (1 ug/ml; Abcam, ab86863, MA, USA), RPL11 (1:3000; Abcam, ab79352, MA, USA) overnight

(8) Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult miceFrontiers in Aging NeuroscienceNovember 8, 2022Xiaoxuan Yang, Chen Chen, Dongmei Qu, Yanping Liu, Ning Wang, Haibi Wang, Youjia Fan, Yushan Zhou, Buwei Yu, Qingsheng Xue, et al.FBXO22 antibody (Abcam Cat# ab230395, United States, Rabbit polyclonal), NMDAR1 antibody (Abcam Cat# ab16895, United States, Mouse monoclonal), PSD-95 antibody (1:000, CST Cat# 3450S, United States, Rabbit polyclonal),

(9) Immunohistochemical Detection and Prognostic Significance of p53, Epidermal Growth Factor Receptor, Murine Double Minute 2, and Isocitrate Dehydrogenase 1 in Glioblastoma Multiforme Patients of PakistanClinical Medicine Insights: OncologyAugust 22, 2022Syed Muhammad Adnan Ali, Muhammad Shahzad Shamim, Syed Ather Enam, Zubair Ahmad, Yumna Adnan, Hasnain Ahmed Farooquirabbit polyclonal IDH1 (Abcam, ab81653; 1:200 dilution), and mouse monoclonal MDM2 (Abcam, clone 2A10, ab16895; 1:100 dilution). Afterwards, these sections were treated with secondary antibody EnVision FLEX + Mouse

(10) The circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axisCell Death DiscoveryFebruary 24, 2022Yu Yan, Yu Nie, Chun Peng, Fuchen Xing, Saiguang Ji, Hong Liu, Chuandong Zhuanti-vimentin (Abcam, #ab92547, 1:1000), anti-snail (Abcam, #ab216347, 1:1000), anti-MDM2 (Abcam, #ab16895, 1:1000), anti-p53 (Abcam, #ab32389, 1:2000), anti-Bcl-2 (Abcam, #ab185002, 1:1000), anti-Bax (Abcam,

(11) The CTCF/LncRNA‐PACERR complex recruits E1A binding protein p300 to induce pro‐tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expressionClinical and Translational MedicineFebruary 20, 2022Yihao Liu et al.were used to prepare the gel for electrophoresis. Antibodies against CTCF (ab26271, Abcam, USA), COX2 (ab16895; Abcam, USA), Glyceraldehyde 3‐phosphate dehydrogenase (GAPDH, 3936; CST), β‐tubulin (2128; CST) and

(12) Vaccinia Virus Arrests and Shifts the Cell CycleVirusesFebruary 19, 2022Caroline K. Martin, Jerzy Samolej, Annabel T. Olson, Cosetta Bertoli, Matthew S. Wiebe, Robertus A. M. de Bruin, Jason Merceranti-phospho-histone γH2A.X Ser139 (Cell Signaling #9718), anti-MCM2 (Cell Signaling #12079), anti-Mdm2 (Abcam ab16895), anti-mouse-HRP (Cell Signaling #7076, 1:5000), anti-mouse-IRDye 680RD (LI-COR 926-68072, 1:10,000),

(13) Preferential translation of p53 target genesRNA biologyJanuary 1, 2022Hisaoka M, Schott J, Bortecen T, Lindner D, Krijgsveld J, Stoecklin G.mouse anti-phospho-Ser139-H2AX (γH2AX) (JBW301, Millipore, 05–636), monoclonal mouse anti-MDM2 (Abcam, ab16895), polyclonal rabbit anti-phospho-Ser51-eIF2α (Cell Signaling, #9721), polyclonal rabbit anti-eIF2α (Cell Signaling

(14) MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathyInternational journal of biological sciencesJanuary 1, 2022Li MR, Lei CT, Tang H, Yin XJ, Hao Z, Qiu Y, Xie YR, Zeng JY, Su H, Zhang C.(1:1000, ab71559, Abcam), Desmin (1:1000, BS1712, Bioworld Technology, Louis Park, MN, USA), MDM2 (1:1000, ab16895, Abcam), active β-catenin (1:1000, #4270, Cell Signaling Technology, Danvers, MA, USA), β-actin (1:10000,

(15) RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathwayRegenerative TherapyDecember 1, 2021Ming Wang, Yifan Huan, Xiyang Li, Jing Li, Guohua Lvantibodies were applied to the membrane at 4 °C overnight. The primary antibodies were mouse anti-MDM2 (ab16895, Abcam), rabbit anti-p53 (ab227655, Abcam), mouse anti-Runx2 (ab76956, Abcam), rabbit anti-Osx (ab227820,

(16) A role for AKT1 in nonsense-mediated mRNA decayNucleic Acids ResearchNovember 8, 2021Martine Palma, Catherine Leroy, Sophie Salomé-Desnoulez, Elisabeth Werkmeister, Rebekah Kong, Marc Mongy, Hervé Le Hir, Fabrice Lejeuneanti-Phospho AKT antibody at 1:2000 (Cell Signaling #4060), rabbit anti-MDM2 antibody at 1:1000 (Abcam ab16895), rabbit anti-CBP80 antibody (H-300) at 1:1000 (Santa Cruz Biotechnology sc-48803), rabbit anti-phospho Ser/Thr ATM/ATR Substrate

(17) Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3Journal of experimental & clinical cancer research : CROctober 6, 2021Jing Y, Jiang X, Lei L, Peng M, Ren J, Xiao Q, Tao Y, Tao Y, Huang J, Wang L, et al.1:1000; Abcam), anti-Cyclin D1 (ab185241, 1:1000; Abcam), anti-Ago2 (ab186733, 1:1000; Abcam), anti-MDM2 (ab16895, 1:1000; Abcam); anti-LC3 (A5179, 1:1000), anti-p62 (A5180, 1:1000), anti-CDK4 (A5189, 1:1000), anti-Bax

(18) PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cellsExperimental and Therapeutic MedicineAugust 2, 2021Jin Woo Shin, Se-Hee Kim, Jin Young YoonInc.), Bax (1:1,000; cat. no. 5023; Cell Signaling Technologies, Inc.), and MDM2 (1:1,000; cat. no. ab16895; Abcam). Goat anti-mouse IgG-HRP (1:5,000; cat. no. sc-2005) and mouse anti-rabbit IgG-HRP (1:5,000;

(19) Inactivation of the tumor suppressor p53 by long noncoding RNA RMRPProceedings of the National Academy of Sciences of the United States of AmericaJuly 20, 2021Chen Y, Hao Q, Wang S, Cao M, Huang Y, Weng X, Wang J, Zhang Z, He X, Lu H, et al.#2947, Cell Signaling Technology), anti-Lamin B (Catalog 66095–1-Ig, Proteintech), anti-MDM2 (Catalog ab16895, Abcam), anti-GAPDH (Catalog 60004–1, Proteintech), and the secondary antibodies for rabbit (Catalog

(20) Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor functionNature communicationsJune 25, 2021Palanikumar L, Karpauskaite L, Al-Sayegh M, Chehade I, Alam M, Hassan S, Maity D, Ali L, Kalmouni M, Hunashal Y, et al.(EPR3993, ab109199; Abcam), Noxa (114C307, sc-56169; Santa Cruz), Bax (E63, ab32503; Abcam) or MDM2 (2A10, ab16895; Abcam) antibodies (1:1000), or β-actin antibody (2A3, sc-517582; Santa Cruz) (1:2000), overnight at

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Anti-MDM2 antibody [2A10] from Abcam

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Anti-MDM2 antibody [2A10] from Abcam

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